•   产品定义

            全基因组关联分析（Genome-wide association study，简称GWAS）是一种在群体水平研究表型-基因型关系的研究策略。GWAS在特定群体中检测全基因组水平数以百万计的分子标记基因型信息的基础上，开展群体中个体表型与基因型的相关性分析，从而解析影响复杂性状的基因变异。随着测序价格的不断下降，全基因组重测序结合GWAS分析，快速定位控制复杂性状的功能性遗传突变，解析对应性状的遗传调控机制，已经成为一种主流的研究方式。

            常见的变异标记，如SNPs、InDels、SVs、PAVs等均可用于GWAS的分析

      文库 测序量
    二代测序

    350-500bp WGS文库

    单个个体≥ 10X

    测序方案

    参考基因组需求 测序个体数
    是 ≥200个个体

     

  •       基于大量自然群体的遗传标记，在全基因组范围内广泛定位与农艺、经济、疾病等性状相关的区域。

    图1 GWAS解析大豆农艺性状关联位点

    图2 转录组结合的GWAS分析定位油菜含油量相关基因

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